Deoxyribonucleic acid flow cytometric analysis of cervical adenocarcinoma: prognostic significance of deoxyribonucleic acid ploidy and S-phase fraction
| Autor: | Jorma Paavonen, Arto Leminen, Matti Forss, Matti Lehtinen, Pirkko Kulomaa, Torsten Wahlström, Ervo Vesterinen |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Aneuploidy Uterine Cervical Neoplasms Biology Adenocarcinoma Flow cytometry chemistry.chemical_compound medicine Humans Stage (cooking) Lymph node Interphase Aged Ploidies medicine.diagnostic_test Cervical adenocarcinoma Obstetrics and Gynecology DNA Middle Aged medicine.disease Flow Cytometry Prognosis Molecular biology medicine.anatomical_structure chemistry Regression Analysis Female Ploidy |
| Zdroj: | American journal of obstetrics and gynecology. 162(3) |
| ISSN: | 0002-9378 |
| Popis: | Paraffin-embedded tumor samples from 125 patients with cervical adenocarcinoma were analyzed by deoxyribonucleic acid flow cytometry. Thirty-one percent of the tumors were aneuploid. Triploid deoxyribonucleic acid content predominated (51.3%) and one third of the deoxyribonucleic acid aneuploid tumors were tetraploid, whereas near-diploid deoxyribonucleic acid aneuploidy was seen infrequently. Deoxyribonucleic acid aneuploidy was associated with tumor size, histologic grade, clinical stage, and high S-phase fraction. Deoxyribonucleic acid ploidy and S-phase fraction value were independent prognostic parameters, together with the presence of lymph node metastases and tumor size. In conclusion, our results indicate that flow cytometric deoxyribonucleic acid analysis helps to predict the prognosis and may thus influence the choice of treatment. |
| Databáze: | OpenAIRE |
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