Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine

Autor:	Arun D.V. Silamkoti, Anita Mehta, Jang Bahadur Gupta, Laxminarayan H. Hegde, Phulen Sarma, Suman Gupta, Shelly Aeron, Naresh Kumar, Kirandeep Kaur, Anita Chugh, Miriyala Bruhaspathy, Shankar Jayram Shetty
Rok vydání:	2005
Předmět:	Tolterodine Tartrate Clinical Biochemistry Phenylpropanolamine Pharmaceutical Science Oxibutinina Biochemistry Chemical synthesis Cresols Structure-Activity Relationship Oxybutynine Drug Discovery medicine Organic chemistry Animals Benzhydryl Compounds Oxybutynin Molecular Biology Receptor Muscarinic M3 Receptor Muscarinic M2 Binding Sites Chemistry Organic Chemistry Rats Design synthesis Drug Design Tolterodina Molecular Medicine Mandelic Acids Tolterodine medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 15(8)
ISSN:	0960-894X
Popis:	Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcb3a41ee9fb692b2046ff7c9c16a66 https://pubmed.ncbi.nlm.nih.gov/15808475 Zobrazit plný text záznamu Full Text from ScienceDirect