The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease
| Autor: | Killimangalam Bhaskar, Michael Chang, Imad Nasser, Michael P. Curry, Raza Malik, Valerie Byrnes, Detlef Schuppan, Nezam H. Afdhal |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Biopsy Gastroenterology Risk Assessment Severity of Illness Index Body Mass Index Adipokines Fibrosis Predictive Value of Tests Risk Factors Internal medicine Lectins Nonalcoholic fatty liver disease medicine Humans Chitinase-3-Like Protein 1 Hyaluronic Acid Glycoproteins Tissue Inhibitor of Metalloproteinase-1 Hepatology medicine.diagnostic_test Keratin-18 business.industry Fatty liver Age Factors Middle Aged medicine.disease Fatty Liver Radiography Diabetes Mellitus Type 2 Liver ROC Curve Predictive value of tests Liver biopsy Disease Progression Biomarker (medicine) Female Steatohepatitis business Biomarkers |
| Zdroj: | Journal of gastroenterology and hepatology. 24(4) |
| ISSN: | 1440-1746 |
| Popis: | Background and Aims: We identified patients with nonalcoholic fatty liver disease (NAFLD) to determine the predictive value of serum markers to diagnose histological steatohepatitis (NASH). Methods: Demographic, serological, radiological and histological variables on 95 consecutive patients with NAFLD were recorded. The serum markers studied were CK18, Hyaluronic acid, TIMP 1 and YKL 40. The NAS score and the metavir score were the histological scoring systems used. Results: CK18 levels were higher in the NASH group compared to the simple steatosis group (394 ± 53 µ/L vs 194 ± 26 µ/L; P |
| Databáze: | OpenAIRE |
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