Famotidine-induced mixed hepatocellular jaundice
Autor: | John D. Roth, Paul W. Ament, Carol J. Fox |
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Rok vydání: | 1994 |
Předmět: |
Male
medicine.medical_specialty Physical examination Cholestasis Intrahepatic Gastroenterology Ranitidine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Cimetidine medicine.diagnostic_test business.industry Jaundice Middle Aged Famotidine Surgery Discontinuation Sucralfate 030220 oncology & carcinogenesis Gastritis medicine.symptom business medicine.drug |
Zdroj: | The Annals of pharmacotherapy. 28(1) |
ISSN: | 1060-0280 |
Popis: | OBJECTIVE: To report a case of probable famotidine-induced mixed hepatocellular jaundice. CASE SUMMARY: A 55-year-old man presented with a one-month history of mid-epigastric pain. Initial physical examination and laboratory studies, including liver enzyme concentration tests, were unrevealing. A diagnosis of gastritis was made and ranitidine was prescribed. Following one week of therapy, the patient's symptoms had not improved and therapy was changed to famotidine and sucralfate. Approximately one week later the patient presented with jaundice. Liver enzyme concentrations were elevated and the patient was hospitalized for further evaluation. Five days following discontinuation of famotidine, liver enzyme concentrations were normal and jaundice had resolved. Further tests did not reveal any pathologic etiology. DISCUSSION: Hepatic changes have occurred in patients receiving histamine2-antagonists; ranitidine and cimetidine have been cited most frequently. In general, the elevations are mild, transient, and return to baseline with continued therapy. This is one of the first case reports of probable famotidine-induced mixed hepatocellular jaundice. CONCLUSIONS: There was a temporal relationship between the patient's signs and symptoms and initiation of famotidine. No identifiable factors contributed to the elevated liver enzyme concentrations and jaundice. |
Databáze: | OpenAIRE |
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