Antioxidant defenses in the ground squirrel Citellus citellus. 2. The effect of hibernation
| Autor: | R. Radojicic, Zorica S. Saičić, Barry Halliwell, B. Buzadžić, V.M. Petrović, Mihajlo B. Spasić |
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| Rok vydání: | 1990 |
| Předmět: |
Hibernation
Male medicine.medical_specialty Antioxidant Free Radicals medicine.medical_treatment Adipose tissue Ascorbic Acid Biochemistry Antioxidants Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Adipose Tissue Brown Physiology (medical) Internal medicine Brown adipose tissue medicine Animals Ground squirrel 030304 developmental biology chemistry.chemical_classification 0303 health sciences Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase Sciuridae Ascorbic acid biology.organism_classification Oxygen Endocrinology medicine.anatomical_structure chemistry biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Free radical biologymedicine. 9(5) |
| ISSN: | 0891-5849 |
| Popis: | In spring and autumn, the ground squirrel Citellus citellus is awake and active but in winter it usually hibernates. Reawakening from hibernation involves intense metabolic activity in the interscapular brown adipose tissue (IBAT). The IBAT of hibernation animals showed significant increases in the activities of superoxide dismutase (both copper-zinc and manganese-containing enzymes), glutathione peroxidase, and in the amount of ascorbate present. Glutathione peroxidase also increased in the liver, as did ascorbate in the plasma. These changes were not merely a consequence of exposure to low environmental temperatures. It is proposed that antioxidant defenses are increased in the IBAT of ground squirrels at the onset of hibernation in order to protect the tissue from reactive oxygen species generated as a result of the intense metabolic activity sustained by this tissue during reawakening. |
| Databáze: | OpenAIRE |
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