Long-term sequelae of congenital gambiense human African trypanosomiasis
| Autor: | David H. Molyneux, Junior Mudji, Johannes Blum, Esther Künzli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Involuntary movement
Adult Pediatrics medicine.medical_specialty Pregnancy Complete physical examination medicine.diagnostic_test business.industry Trypanosoma brucei gambiense Public Health Environmental and Occupational Health Muscle Tonus Physical examination General Medicine medicine.disease Infectious Diseases Trypanosomiasis African medicine Animals Humans Parasitology Lack of knowledge African trypanosomiasis Presentation (obstetrics) business Child |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 115(8) |
| ISSN: | 1878-3503 |
| Popis: | Background The clinical presentation of gambiense human African trypanosomias (gHAT) is generally considered to be the same among children and adults. In general, when describing the clinical presentation of children with gHAT, no differentiation is made between congenital gHAT and gHAT acquired later. There is a lack of knowledge regarding the signs and symptoms attributable to congenital gHAT and its long-term sequelae. Methods Following an evaluation of the hospital register for gHAT, the authors observed that six children born to mothers with gHAT during their pregnancies still had sequelae of the infection. The six mothers were interviewed about their respective pregnancies and the developmental history of the children borne to the infected mothers. Furthermore, the children then underwent a complete physical examination with a focus on neuropsychiatric signs and symptoms. Results Five of the six patients are still seriously disabled. Behavioral changes are present in four patients, tremor, speech impairment, involuntary movements and pathologic the Barrés test and Mingazzini test in three patients and convulsions, pyramidal signs and decreased muscle tonus in two patients. Two patients cannot work and one has a sphincter disorder. Conclusions Our study suggests that congenital gHAT may lead to long-lasting sequelae in babies born to mothers treated after delivery. The risk of embryo toxicity of treatment of mothers with gHAT must be balanced against the risk of congenital gHAT with long-term sequelae. |
| Databáze: | OpenAIRE |
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