The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction
| Autor: | Maciej Banach, Małgorzata Misztal, Agata Bielecka-Dabrowa, Agata Sakowicz, Piotr Chruściel, Tadeusz Pietrucha, Jacek Rysz |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Genotype Science Renal function Single-nucleotide polymorphism 030204 cardiovascular system & hematology Biology Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Aged Heart Failure Diastolic Multidisciplinary Ejection fraction Diastolic heart failure Interleukin Middle Aged medicine.disease Prognosis Endocrinology Heart failure Hypertension Medicine Female Complications of hypertension |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2045-2322 |
| Popis: | The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A].110 patients with HF with preserved and mid-range ejection fraction (HFpEF and HFmrEF) were recruited. GG homozygotes in 174 G/C of IL6 polymorphism are characterized by higher values of estimated glomerular filtration rate based on the study Modification of Diet in Renal Disease (eGFR MDRD) and C allele in the NOS polymorphism and AA profile in C-1260A of CYP27B1 polymorphism correlated with a lower eGFR (MDRD). In multivariate analysis the CG genotype for 174 G/C of IL-6 and allele A in C-1260A of CYP27B1 are the only SNPs independently associated with worse course of HFpEF and HFmrEF. These data confirm the importance of the selected SNPs in aggravation and complications of hypertension. |
| Databáze: | OpenAIRE |
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