Bullous eczema presenting as bullous pemphigoid-like eruption: A case series
| Autor: | George Atteh, Emily F. Cole, Adam J Perricone, Ron J. Feldman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
bullous pemphigoid
medicine.medical_specialty Peripheral edema BP bullous pemphigoid Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine general dermatology Diabetes mellitus Biopsy PBP prodromal bullous pemphigoid medicine lcsh:Dermatology Case Series Direct fluorescent antibody ELISA enzyme-linked immunoassay medicine.diagnostic_test business.industry IIF indirect immunofluorescence Autoantibody Arthropod assault IIf lcsh:RL1-803 medicine.disease autoimmune blistering disease 030220 oncology & carcinogenesis DIF direct immunofluorescence bullous eczema Bullous pemphigoid eczema medicine.symptom business |
| Zdroj: | JAAD Case Reports, Vol 10, Iss, Pp 34-37 (2021) JAAD Case Reports |
| ISSN: | 2352-5126 |
| Popis: | Bullous pemphigoid (BP) is an autoimmune blistering disease resulting from autoantibodies directed against BP180 and/or BP230 proteins. BP is traditionally diagnosed based on clinical features, histologic assessment of cutaneous biopsies, direct (DIF) and indirect immunofluorescence (IIF) studies, and/or enzyme-linked immunoassay (ELISA) analysis. We here report, 6 elderly patients who presented with multiple tense bullae, clinically mimicking BP in the absence of detectable autoantibodies by DIF, IIF, and ELISA for BP-180, BP-230, and type VII collagen autoantibodies. All patients in this case series had histological overlap between BP and eczema, potentially representing a unique form of bullous eczema. Patient demographics are listed in Table I along with clinical images (Fig 1). Patients were evaluated in the Autoimmune Blistering Disease Clinic at Emory University. All patients had at least 2 negative DIFs on 2 separate occasions. Only 1 patient was subject to systemic immune suppression at the time of biopsy, and no history of diabetes, peripheral edema, or arthropod assault was noted. Table I Clinical summary of patients 1 to 6 |
| Databáze: | OpenAIRE |
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