The Effects of Long-term Colchicine Therapy on Male Fertility in Patients with Familial Mediterranean Fever
| Autor: | M. Levy, E.J. Margalioth, M. Ehrenfeld, M. Eliakim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Infertility medicine.medical_specialty Pediatrics Time Factors Sterility Urology medicine.medical_treatment media_common.quotation_subject Familial Mediterranean fever Fertility chemistry.chemical_compound Endocrinology medicine Humans Colchicine Pathological Infertility Male media_common Sperm-Ovum Interactions Azoospermia Chemotherapy business.industry General Medicine Middle Aged medicine.disease Familial Mediterranean Fever Surgery chemistry Cervix Mucus Female business |
| Zdroj: | Andrologia. 18:420-426 |
| ISSN: | 0303-4569 |
| DOI: | 10.1111/j.1439-0272.1986.tb01801.x |
| Popis: | Four out of 19 male patients suffering from familial Mediterranean fever (FMF) had fertility problems while on colchicine therapy (0.5-2.0 mg daily for as long as 11 years). Three of the patients had had children while off therapy but their wives could not conceive while they were on therapy. In one patient primary sterility remained one year after cessation of colchicine. In this and two other patients the spermiogram was normal but the sperm penetration test was pathological. The fourth patient had azoospermia. Patients should be informed about this possible risk of colchicine therapy. The need for continued follow-up and the value of the sperm penetration test in the detection of fertility problems in male patients on long-term colchicine therapy are stressed. It is concluded however, that overall the benefits outweigh the danger of long-term colchicine treatment in male patients with FMF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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