Clinical and Microbiological Features of Asymptomatic SARS-CoV-2 Infection and Mild COVID-19 in Seven Crewmembers of a Cruise Ship
| Autor: | Kunihiro Yamaoka, Tatsuhiko Wada, Shin Nihonyanagi, Ryo Kameda, Yoko Takayama, Minako Yamaoka-Tojo, Jyunya Ako, Takayuki Hoshiyama, Michinari Fukuda |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Exacerbation secondary bacterial infection medicine.disease_cause Asymptomatic Polymerase Chain Reaction Haemophilus influenzae Sputum culture coronavirus disease 2019 Young Adult Risk Factors Throat Internal medicine Internal Medicine Medicine Humans Asymptomatic Infections Pandemics Ships Coronavirus sputum culture medicine.diagnostic_test business.industry SARS-CoV-2 COVID-19 General Medicine Middle Aged medicine.disease Pneumonia medicine.anatomical_structure Sputum RNA Viral Original Article Female medicine.symptom business severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective To describe the clinical features and clinical course of individuals diagnosed with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or mild coronavirus disease (COVID)-19. Patients The study participants consisted of 7 crewmembers of the passenger cruise-liner, Diamond Princess, who were admitted to our hospital after becoming infected with SARS-CoV-2 aboard the ship. Methods The data on patient background and biochemical test results were obtained from the patients' medical records. All patients had a chest X-ray, and a throat swab and sputum samples were sent for culture on admission. Results The median age of the 7 patients, of whom 4 were male and 3 were female, was 39 years (range: 23-47 years). On admission, none of them had fever, but 4 (57%) had a cough. None of them showed any signs of organ damage on laboratory testing. Chest X-ray showed pneumonia in one individual, which resolved spontaneously, while the other 6 had normal chest X-ray findings. Culture of throat swabs and sputum samples revealed that 4 patients (57%) had bacterial upper respiratory infections (Haemophilus influenzae, Klebsiella pneumoniae, and Staphylococcus aureus). The period from a positive polymerase chain reaction (PCR) test to negative conversion ranged from 5 to 13 days, with a median of 8 days. Conclusion Healthy young adults without risk factors who acquire SARS-CoV-2 infection may have an asymptomatic infection or may experience mild COVID-19. In addition to obesity, an older age, underlying illness, and being overweight can lead to a risk of exacerbation; thus, hospital management for such individuals may be desirable. Culturing respiratory samples may be useful for diagnosing secondary bacterial pneumonia. |
| Databáze: | OpenAIRE |
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