Serological reactivity and viral genotypes in hepatitis C virus infection
| Autor: | Mauro Pistello, C M Avio, F. Panicucci, Nadia Cecconi, Fabrizio Maggi, Mauro Bendinelli, Ml Vatteroni |
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| Předmět: |
Microbiology (medical)
Adult Male Adolescent Genotype Hepatitis C virus Immunoblotting medicine.disease_cause Polymerase Chain Reaction Virus Serology Flaviviridae medicine Humans Hepatitis Antibodies Serotyping Child Aged Aged 80 and over biology Hepatitis C Antibodies Middle Aged biology.organism_classification Virology Hepatitis C Immunology biology.protein Female Viral disease Reagent Kits Diagnostic Antibody Viral genotype Research Article |
| Zdroj: | Scopus-Elsevier |
| Popis: | Patients infected with hepatitis C virus (HCV) were examined with four commercial HCV immunoblotting assays and for anti-GOR antibody to ascertain whether serological findings varied with the genotype of the infecting virus. The results indicate that patients infected with different HCV genotypes tend to show different immunoblotting profiles, mainly due to a low prevalence of antibodies to the viral region NS4 in patients infected with genotypes III and IV. Differences were more evident with second- than with third-generation assays. Patients infected with genotype IV exhibited a lower prevalence of anti-GOR antibody than patients infected with other genotypes. |
| Databáze: | OpenAIRE |
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