Effects of Sugar‐Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial
| Autor: | Cara B. Ebbeling, Nicolle Quinn, Henry A. Feldman, Sarah K. Steltz, Lisa Robinson, David S. Ludwig |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male beverages Adolescent 030209 endocrinology & metabolism Body weight law.invention body weight Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Risk Factors law Environmental health medicine Humans Obesity 030212 general & internal medicine Preventive Cardiology Sugar Triglycerides Original Research Diet and Nutrition Sugar-Sweetened Beverages Cardiometabolic risk business.industry dyslipidemia Cholesterol HDL Cardiometabolic Risk Factors Sweet taste Lifestyle medicine.disease sweet taste preference Preference Primary Prevention Obesity Abdominal Sweetening Agents Taste Body Composition Female diet Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| DOI: | 10.1161/jaha.119.015668 |
| Popis: | BackgroundA 2018 American Heart Association science advisory indicated that, pending further research, artificially sweetened beverages (ASBs) may be an appropriate initial replacement for sugar‐sweetened beverages (SSBs) during transition to unsweetened beverages (USBs).Methods and ResultsWe randomly assigned 203 adults (121 males, 82 females; 91.6% retention), who habitually consumed SSBs, to 3 groups and delivered free SSBs, ASBs, or USBs to their homes for 12 months. Outcomes included serum triglyceride to high‐density lipoprotein cholesterol ratio (primary), body weight, and sweet taste preference (experimental assessment, 0%–18% sucrose solutions). Change in serum triglyceride to high‐density lipoprotein cholesterol ratio was not different between groups. Although overall change in weight also was not different between groups, we found effect modification (P=0.006) by central adiposity. Among participants in the highest tertile of baseline trunk fat but not other tertiles, weight gain was greater (P=0.002) for the SSB (4.4±1.0 kg, estimate±SE) compared with ASB (0.5±0.9 kg) or USB (−0.2±0.9 kg) group. Both sweetness threshold (–1.0±0.2% m/v;P=0.005) and favorite concentration (–2.3±0.4% m/v;PP=0.02). Pairwise comparison between the ASB and USB groups indicated a difference in sweetness threshold (P=0.015).ConclusionsReplacing SSBs with noncaloric beverages for 12 months did not affect serum triglyceride to high‐density lipoprotein cholesterol ratio. Among individuals with central adiposity, replacing SSBs with either ASBs or USBs lowered body weight. However, USBs may have the most favorable effect on sweet taste preference.RegistrationURL:https://www.clinicaltrials.gov; unique identifier: NCT01295671. |
| Databáze: | OpenAIRE |
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