A risk score for predicting pulmonary hypertension in patients with non-transfusion-dependent thalassemia in northeastern Thailand: The E-SAAN score
| Autor: | Suporn Chuncharunee, Burabha Pussadhamma, Chittima Sirijerachai, Phuangpaka Ungprasert, Bandit Thinkhamrop, Saranya Pongudom, Kanchana Chansung, Patcharawadee Prayalaw, Arunee Jetsrisuparb, Nattiya Teawtrakul, Chinadol Wanitpongpun, Supan Fucharoen, Srisuda Thongbuaban |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hypertension Pulmonary medicine.medical_treatment Thalassemia Splenectomy Logistic regression Predictive Value of Tests Risk Factors Internal medicine medicine Humans In patient Child Ultrasonography Framingham Risk Score business.industry beta-Thalassemia Non transfusion dependent thalassemia Hematology medicine.disease Pulmonary hypertension Tricuspid Valve Insufficiency Surgery Hemoglobin E Female business |
| Zdroj: | Hematology. 20:416-421 |
| ISSN: | 1607-8454 |
| Popis: | Introduction: Pulmonary hypertension (PH) is a major complication in patients with non-transfusiondependent thalassemia (NTDT). The risk score was developed to be a screening test for PH risk in these patients. Methods: A multi-center study was conducted in patients with NTDT aged ≥10 years old. PH risk was defined as tricuspid regurgitation velocity >2.9 m/s by echocardiography. The clinical parameters significantly associated with PH were entered into the logistic regression model. Results: The E-SAAN score included (1) age >35 years (2.5 points), (2) time after splenectomy >5 years (2.5 points), and (3) β-thalassemia/hemoglobin E (2 points). Using the cut-off point of 4.5 points, the score showed a good discrimination in the validating group with an area under receiver-operating characteristics curve of 0.88 (95% CI 0.8–0.95). Conclusion: The E-SAAN score is a simple and practical score which can be used as a screening test for PH risk in patients with NTDT. |
| Databáze: | OpenAIRE |
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