Effects of early unilateral blur on the macaque's visual system. I. Behavioral observations

Autor:	L, Kiorpes, R G, Boothe, A E, Hendrickson, J A, Movshon, H M, Eggers, M S, Gizzi
Rok vydání:	1987
Předmět:	Atropine genetic structures Critical Period Psychological General Neuroscience Articles Amblyopia Refractive Errors eye diseases Discrimination Learning Space Perception Visual Perception Animals Evoked Potentials Visual Macaca nemestrina Sensory Deprivation Vision Ocular
Zdroj:	The Journal of Neuroscience. 7:1318-1326
ISSN:	1529-2401 0270-6474
DOI:	10.1523/jneurosci.07-05-01318.1987
Popis:	We raised 8 macaque monkeys with chronic atropinization of one eye throughout the first 6–10 months after birth. This rearing procedure produces retinal image blur, with the most pronounced contrast attenuation occurring at high spatial frequencies. Measurements of contrast sensitivity were made using behavioral methods in 6 monkeys and evoked potential methods in 2 monkeys. The results showed that this rearing procedure produced long-term deficits in the contrast sensitivity and spatial resolution of the atropinized eye, which were not due to residual losses in accommodative capacity. There was considerable interanimal variation in the magnitude of the effects on visual performance. Similar losses in visual performance are seen in some forms of human amblyopia. Rearing monkeys with chronic instillation of atropine therefore provides a nonhuman primate model for studying the underlying neural mechanisms of anisometropic amblyopia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db98fea80c5d66e6ccf06746755833d https://doi.org/10.1523/jneurosci.07-05-01318.1987 Zobrazit plný text záznamu