Identification of potential blood-derived extracellular vesicles biomarkers to diagnose and predict distant metastases in ER+ breast cancer patients
| Autor: | Zia Hamidi, Eduardo Tejero, Rod Tucker, Ana Pedro, Ronny Schmidt |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
CA15-3
0303 health sciences business.industry medicine.drug_class Serum amyloid A1 medicine.disease Metastatic breast cancer Extracellular vesicles 3. Good health Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Er breast cancer Estrogen 030220 oncology & carcinogenesis medicine Cancer research business 030304 developmental biology |
| DOI: | 10.1101/202291 |
| Popis: | The objective of this study was to identify potential extracellular vesicles (EV) which might serve as biomarkers for predictive and diagnostic purposes in metastatic breast cancer. Plasma samples from 7 different metastatic and non-metastatic ER+ (estrogen receptor -positive) breast cancer patients were collected, EV were isolated and their protein content analyzed by mass spectrometry and FunRich analysis. In this study we found several putative plasma EV biomarkers for metastatic ER+ breast cancer prediction and diagnosis, such as serum amyloid A1, known to promote widespread metastasis in a breast cancer animal model. |
| Databáze: | OpenAIRE |
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