Functions of Hsp90-Binding FKBP immunophilins
| Autor: | Marc B. Cox, Mario D. Galigniana, Yenni A. Garcia, Jeffrey C. Sivils, Naihsuan Guy |
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| Přispěvatelé: | Blatch, Gregory L., Edkins, A. L. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Networking of chaperones by Co-chaperones Subcellular Biochemistry ISBN: 9783319117300 |
| DOI: | 10.1007/978-3-319-11731-7_2 |
| Popis: | Hsp90 functionally interacts with a broad array of client proteins, but in every case examined Hsp90 is accompanied by one or more co-chaperones. One class of co-chaperone contains a tetratricopeptide repeat domain that targets the co-chaperone to the C-terminal region of Hsp90. Within this class are Hsp90- binding peptidylprolyl isomerases, most of which belong to the FK506-binding protein (FKBP) family. Despite the common association of FKBP co-chaperones with Hsp90, it is now clear that the client protein influences, and is influenced by, the particular FKBP bound to Hsp90. Examples include Xap2 in aryl hydrocarbon receptor complexes and FKBP52 in steroid receptor complexes. In this chapter, we discuss the known functional roles played by FKBP co-chaperones and, where possible, relate distinctive functions to structural differences between FKBP members. Fil: Guy, Naihsuan C.. University of Texas at El Paso; Estados Unidos Fil: Garcia, Yenni A.. University of Texas at El Paso; Estados Unidos Fil: Sivils, Jeffrey. University of Texas at El Paso; Estados Unidos Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Cox, Marc B.. University of Texas at El Paso; Estados Unidos |
| Databáze: | OpenAIRE |
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