OVULATION INDUCTION AND ANTIFERTILITY EFFECTS OF AN LH-RH ANALOGUE (AY-25,205) IN CYCLIC RATS
| Autor: | M. L. Givner, U. K. Banik |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Ovulation
Fluphenazine Embryology medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone Sexual Behavior Animal Endocrinology Estrus Pregnancy Internal medicine medicine Animals Endocrine system media_common Estrous cycle Dose-Response Relationship Drug business.industry Obstetrics and Gynecology Cell Biology medicine.disease Hormones Rats Fertility Reproductive Medicine Female Ovulation induction business medicine.drug Hormone |
| Zdroj: | Reproduction. 44:87-94 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/jrf.0.0440087 |
| Popis: | Pro-oestrous rats, treated with fluphenazine dihydrochloride to block ovulation, were used to compare the ovulation-inducing activity of synthetic LH-RH with one of its analogues, [D-Ala-6, des-Gly-NH2-10]-LH-RH ethylamide (AY-25,205). The lowest dose of LH-RH which produced a significant response was 125 ng compared with 2.9 ng AY-25,205. Statistical analysis of the data showed that AY-25,205 was approximately thirty-six times more potent than LH-RH. Treatment with AY-25,205 also induced partial ovulation in metoestrous rats (80 or 160 ng/rat) and apparently normal ovulation in dioestrous rats (10 to 160 ng/rat). The compound (160 ng) failed to induce further ovulation in oestrous rats which ovulated during the previous night. Advancement of premature ovulation in dioestrous rats with AY-25,205 prevented mating behaviour and pregnancy during the treatment cycle. The antifertility effect of the compound disappeared during the following cycle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|