Influence of Disease Manifestations on Health-related Quality of Life in Early Psoriatic Arthritis
| Autor: | K. Wervers, Cathelijne W. Y. Appels, Johanna M. W. Hazes, Lindy-Anne Korswagen, Marijn Vis, Josien J. Veris-van Dieren, Wiebo L. van der Graaff, Marc R. Kok, Johannes H L M van Groenendael, Andreas H. Gerards, Ilja Tchetverikov, Jolanda J. Luime |
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| Přispěvatelé: | Rheumatology |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Arthritis Enthesopathy Dactylitis Cohort Studies 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Rheumatology Internal medicine Psoriasis medicine Back pain Immunology and Allergy Humans 030212 general & internal medicine Netherlands 030203 arthritis & rheumatology Oligoarthritis business.industry Arthritis Psoriatic Enthesitis Middle Aged medicine.disease Quality of Life Polyarthritis Female medicine.symptom business |
| Zdroj: | Journal of Rheumatology, 45(11), 1526-1531. Journal of Rheumatology |
| ISSN: | 1499-2752 0315-162X |
| Popis: | Objective.Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA and analyze its associations with disease manifestations.Methods.Data collected at time of diagnosis from patients with PsA included in the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR) study were used. HRQOL was assessed using 8 domains of the Medical Outcomes Study Short Form-36 (SF-36) questionnaire. Patients were classified based on primary manifestation in arthritis subtypes (i.e., mono-, oligo-, or polyarthritis) and other subtypes (i.e., enthesitis, dactylitis, and axial disease). In all patients, presence of arthritis, enthesitis, dactylitis, psoriasis, and chronic inflammatory back pain was determined. Multivariable linear regression was used to determine associations of PsA manifestations with HRQOL.Results.Of 405 patients, primary manifestation was peripheral arthritis in 320 (78 monoarthritis, 151 oligoarthritis, and 91 polyarthritis), enthesitis in 37, axial disease in 9, and dactylitis in 39. Mean scores of SF-36 domains were lower than the Dutch reference population and similar across arthritis subtypes. A higher number of enthesitis locations and tender joints, and presence of chronic back pain, were independently associated with worse SF-36 scores. Psoriasis and dactylitis were not associated with worse scores.Conclusion.HRQOL was diminished in PsA at time of diagnosis compared to the Dutch reference population, and tender joints, enthesitis at clinical examination, and back pain as indicators of pain affected HRQOL. |
| Databáze: | OpenAIRE |
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