BMP2 and BMP7 play antagonistic roles in feather induction
| Autor: | Frederic Michon, Jacques Demongeot, Danielle Dhouailly, Elodie Collomb, Loic Forest |
|---|---|
| Přispěvatelé: | Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), TIMB, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Dhouailly, Danielle, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
skin
animal structures Bone Morphogenetic Protein 7 Integrin alpha4 Cellular differentiation Morphogenesis Bone Morphogenetic Protein 2 Chick Embryo migration Models Biological Article 03 medical and health sciences 0302 clinical medicine Dermis Cell Movement [SDV.BDD] Life Sciences [q-bio]/Development Biology medicine Animals chemotaxis Fibronectin [SDV.BDD]Life Sciences [q-bio]/Development Biology Molecular Biology Body Patterning 030304 developmental biology 0303 health sciences integumentary system biology Epidermis (botany) fungi food and beverages Cell Differentiation Chemotaxis Cell migration Feathers Skin appendage Fibronectins dermis Cell biology cutaneous appendage medicine.anatomical_structure embryonic structures Immunology biology.protein Epidermis mathematical model 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2008, 135 (16), pp.2797-805. ⟨10.1242/dev.018341⟩ Development (Cambridge, England), 2008, 135 (16), pp.2797-805. ⟨10.1242/dev.018341⟩ |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.018341 |
| Popis: | International audience; Feathers, like hairs, first appear as primordia consisting of an epidermal placode associated with a dermal condensation that is necessary for the continuation of their differentiation. Previously, the BMPs have been proposed to inhibit skin appendage formation. We show that the function of specific BMPs during feather development is more complex. BMP2 and BMP7, which are expressed in both the epidermis and the dermis, are involved in an antagonistic fashion in regulating the formation of dermal condensations, and thus are both necessary for subsequent feather morphogenesis. BMP7 is expressed earlier and functions as a chemoattractant that recruits cells into the condensation, whereas BMP2 is expressed later, and leads to an arrest of cell migration, likely via its modulation of the EIIIA fibronectin domain and alpha4 integrin expression. Based on the observed cell proliferation, chemotaxis and the timing of BMP2 and BMP7 expression, we propose a mathematical model, a reaction-diffusion system, which not only simulates feather patterning, but which also can account for the negative effects of excess BMP2 or BMP7 on feather formation. |
| Databáze: | OpenAIRE |
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