Transcription factor Atf1‐dependent degradation of the mitotic cyclin Cdc13 is regulated by multiple factors in Schizosaccharomyces pombe

Autor:	Sohini Basu, ProtitiMaiti Ghosh, Agamani Ghosal, Suchismita Datta, Geetanjali Sundaram
Rok vydání:	2022
Předmět:	Activating Transcription Factor 1 Biophysics Cell Cycle Proteins Cell Biology Protein-Tyrosine Kinases Phosphoproteins Biochemistry Structural Biology Cyclins CDC2 Protein Kinase Schizosaccharomyces Genetics Schizosaccharomyces pombe Proteins Phosphorylation Molecular Biology Transcription Factors
Zdroj:	FEBS Letters. 596:2021-2030
ISSN:	1873-3468 0014-5793
Popis:	The bZIP transcription factor Atf1 is a key player in the transcriptional programme of Schizosaccharomyces pombe cell cycle. It also controls both expression and degradation of mitotic cyclin Cdc13. Temporal regulation of these opposing functions of Atf1 is critical for fidelity of cell division. Our investigations revealed that an increase in the activity of mitogen-activated protein kinase (MAPK) Spc1 during mitotic exit and the consequent phosphorylation of Atf1 along with the prevailing high activity of cyclin-dependent kinase Cdc2 regulate Cdc13 degradation. Our results also indicate the possibility of a complex interplay between Cdc2 inhibitory kinase Wee1, the anaphase-promoting complex and Atf1 during mitotic exit. These observations provide evidence of new regulatory mechanisms of mitotic exit.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db4f68253854058f2ffe7edb42bd6ad https://doi.org/10.1002/1873-3468.14439 Zobrazit plný text záznamu Plný text