Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit
| Autor: | Ri-Long Yang, Ying-Jie Zhu, Yong-Gang Zhang, Fei-Fei Chen, Zhi-Chao Xiong, Zi-Yue Yang |
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| Rok vydání: | 2017 |
| Předmět: |
Silver
Materials science Aqueous solution Biocompatibility Nanowires Reducing agent Nanowire Metal Nanoparticles Biomaterial Nanotechnology Microbial Sensitivity Tests 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Silver nanoparticle Anti-Bacterial Agents 0104 chemical sciences Durapatite Specific surface area Drug delivery General Materials Science 0210 nano-technology Nuclear chemistry |
| Zdroj: | ACS Applied Materials & Interfaces. 9:22212-22222 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Hydroxyapatite is a kind of biocompatible, environmentally friendly, and versatile inorganic biomaterial. Herein, the preparation of ultralong hydroxyapatite nanowires (HAPNWs)-based antibacterial paper co-loaded with silver nanoparticles (AgNPs) and antibiotic is reported. HAPNWs are used to prepare AgNPs in situ using an aqueous solution containing AgNO3 under the sunlight without added reducing agent at room temperature. Subsequently, ciprofloxacin (CIP) as an antibiotic is loaded on the HAPNWs@AgNPs. The resultant HAPNWs@AgNPs-CIP paper possesses several unique properties, including high flexibility, high Brunauer–Emmett–Teller (BET) specific surface area (47.9 m2 g–1), high drug loading capacity (447.4 mg g–1), good biocompatibility, sustained and pH-responsive drug release behavior (5.40–6.75% of Ag+ ions and 37.7–76.4% of CIP molecules at pH values of 7.4–4.5 at day 8, respectively), and reusable recycling. In the antibacterial tests against Escherichia coli and Staphylococcus aureus, the HAPNWs@Ag... |
| Databáze: | OpenAIRE |
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