Associations between Apolipoprotein E Gene Polymorphism, Diet and Dyslipidemia in a Yao Minority Area, China
| Autor: | Tingyu Mai, Zhiyong Zhang, Huaxiang Lu, Qiumei Liu, You Li, Xu Tang, Jian Qin, Jiansheng Cai, Min Xu, Haoyu He, Xia Xu, Chunbao Mo, Junling Zhang, Shuzhen Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Apolipoprotein E China Physiology symbols.namesake Apolipoproteins E Polymorphism (computer science) Genotype Dietary Carbohydrates Humans Medicine Allele Dyslipidemias Polymorphism Genetic business.industry Fatty Acids Cholesterol LDL medicine.disease Dietary Fats Confidence interval Diet Bonferroni correction Saturated fatty acid symbols business Dyslipidemia |
| Zdroj: | Journal of the American Nutrition Association. 41:690-696 |
| ISSN: | 2769-707X 2769-7061 |
| DOI: | 10.1080/07315724.2021.1953415 |
| Popis: | Objective This study aimed to assess the effects of Apolipoprotein E (APOE) gene polymorphisms, dietary nutrient intake, and their interactions on the prevalence of dyslipidemia in a Yao minority area, China. Methods rs429358, rs7412, rs7259620, and rs405509 of the APOE gene were genotyped in 1014 adults aged ≥30 years by using the MassArray system. Dietary nutrients intake data were ascertained from a 109-item food frequency questionnaire (FFQ). Results Multifactorial logistics regression analysis showed that dyslipidemia was associated with rs7412-CT/TT genotype (OR: 0.540, Bonferroni correction confidence interval: 0.336-0.869), high fat intake (OR: 1.644, 95% CI: 1.128-2.395), high saturated fatty acid (SFA) intake (OR: 1.668, 95% CI: 1.146-2.428), medium carbohydrate intake (OR: 0.634, 95% CI: 0.461-0.873) and high carbohydrate intake (OR: 0.591, 95% CI: 0.406-0.858). The results of logistics regression multiplication model showed that medium carbohydrate intake in the carriers of the rs7412 minor alleles was associated with a low risk of dyslipidemia (OR: 0.433, Bonferroni correction confidence interval: 0.199-0.941). Conclusions Genetic variations at the rs7412, dietary fat, SFA, and carbohydrate intake and the interaction between APOE gene polymorphisms and carbohydrate intake are associated with dyslipidemia in Yao nationality people. |
| Databáze: | OpenAIRE |
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