Development and physicochemical characterization of clindamycin resinate for taste masking in pediatrics
| Autor: | Baher Daihom, Lijia Wang, Alaadin Alayoubi, Sanjay R. Mishra, Richard A. Helms, Hassan Almoazen, Dejian Ma |
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| Rok vydání: | 2016 |
| Předmět: |
Administration
Oral Pharmaceutical Science 02 engineering and technology Amberlite Pediatrics 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Suspensions stomatognathic system Drug Discovery medicine Taste masking Ion-exchange resin Pharmacology Aqueous solution Chromatography Chemistry Clindamycin Organic Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology Drug Liberation Resins Synthetic Taste Binding study Clindamycin hcl Chemical stability Ion Exchange Resins 0210 nano-technology Tablets medicine.drug |
| Zdroj: | Drug Development and Industrial Pharmacy. 42:1600-1608 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639045.2016.1160104 |
| Popis: | To evaluate the physicochemical characteristics of clindamycin HCl in a complex form (resinate) with ion exchange resin (IER) (Amberlite IRP69).Drug-resin complex was prepared by simple aqueous binding method. Drug binding study was carried out at different drug and resin concentrations. Several physicochemical characterization studies were conducted to evaluate the resinate complex. These studies included flow properties, in vitro drug release in SGF and SIF, DSC, TGA, mass spectroscopy and XPRD evaluations. In addition, stability study of resinate complex was conducted at 25 and 40 °C for up to 1 month.Clindamycin and Amberlite IRP69 have formed a complex (resinate) and have shown good flow properties, good thermal properties and chemical stability (short term over 4 weeks) at 25 and 40 °C. Clindamycin release profiles from resinate in SGF and SIF have shown immediate release characteristics and release in simulated saliva has shown dependence on water volume.The clindamycin stable complex with IER (Amberlite IRP69) has the potential for further development as a compatible pediatric liquid formulation (suspension) or a fast disintegrating tablet. |
| Databáze: | OpenAIRE |
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