Glycosaminoglycans of Human Prostatic Cancer
| Autor: | D.P. De Klerk, H.J. Human, D.V. Lee |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Urology Prostatic Stroma Prostatic Hyperplasia Dermatan Sulfate Dermatan sulfate Glycosaminoglycan chemistry.chemical_compound Sulfation Prostate Humans Medicine Chondroitin sulfate Hyaluronic Acid Aged Glycosaminoglycans Histocytochemistry business.industry Chondroitin Sulfates Prostatic Neoplasms Cancer Heparan sulfate Middle Aged medicine.disease carbohydrates (lipids) Uronic Acids medicine.anatomical_structure chemistry Biochemistry Cancer research Heparitin Sulfate business |
| Zdroj: | Journal of Urology. 131:1008-1012 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)50750-8 |
| Popis: | The glycosaminoglycans of normal, benign hyperplastic and cancerous prostate were studied. In both prostatic hyperplasia and cancer the chondroitin sulfate:dermatan sulfate ratio was increased. In prostatic cancer this increase correlated with both the differentiation and extent of cancer in the prostate. The percentages heparan sulfate and heparan sulfate sulfation were decreased in prostatic cancer. Hyaluronic acid increased with dedifferentiation of the cancer. Histochemically, sulfated glycosaminoglycans were concentrated in the prostatic stroma at the stromal-epithelial interface. The increased chondroitin sulfate:dermatan sulfate ratio may be a nonspecific response or requirement for epithelial growth. |
| Databáze: | OpenAIRE |
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