The effect of optic neuritis treatment trial (ONTT) combined corticosteroid regimen on pattern reversal visual evoked potentials: a prospective follow-up study
Autor: | Manoji Pathirage, Saman Senanayake, Tharaka L. Dassanayake, Vajira S. Weerasinghe, Mike Sedgwick, Padmini Dahanayake |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Visual acuity genetic structures medicine.drug_class Optic neuritis Visual evoked potentials Treatment trial Adrenal Cortex Hormones Ophthalmology medicine Visual conduction Humans Corticosteroids Prospective Studies Prospective study Prospective cohort study P100 business.industry Research General Medicine RE1-994 medicine.disease eye diseases Regimen P100 Latency Remyelination Corticosteroid Evoked Potentials Visual ONTT combined regimen medicine.symptom business Follow-Up Studies |
Zdroj: | BMC Ophthalmology, Vol 21, Iss 1, Pp 1-9 (2021) BMC Ophthalmology |
ISSN: | 1471-2415 |
Popis: | Background The combined corticosteroid regimen of the original Optic Neuritis Treatment Trial (ONTT) is used in many centers to treat optic neuritis. Though pattern reversal visual evoked potentials (PRVEPs) are a sensitive, standard measure of visual conduction in optic neuritis, no studies hitherto have investigated the effect of combined ONTT regimen on PRVEPs. We aimed to determine the effect of combined corticosteroid regimen of the ONTT on changes of PRVEPs in patients with first-episode optic neuritis over 3 months post-treatment. Methods This is a prospective, observational study in which 44 patients with optic neuritis were seen pre-treatment (baseline) and follow-up, at 1 month (FU1) and 3 months (FU2). Twenty-nine patients were treated with ONTT combined regimen (ONTT+ Group) while 15 were conservatively managed without corticosteroids (ONTT- Group). The median latency and amplitude values of the P100 PRVEP component and the visual acuity (i.e. LogMAR values) at pre-treatment, FU1 and FU2 were compared in the two groups using Friedman’s rank test and Wilcoxon Signed Ranks test. Results Median P100 latency improved significantly (to the normal range) as early as by 1 month after the commencement of treatment in the ONTT+ Group, and then remained significantly lower than the baseline over next 2 months. In the ONTT- Group, the median P100 latency improved more slowly over the two follow up assessments and reached the normal range by 3 months. Median visual acuity values also improved significantly at 1 and 3 months after the commencement of treatment in the ONTT+ Group but not in the ONTT- Group. Conclusion ONTT combined corticosteroid regimen improves conduction in the visual pathways of patients with first-episode optic neuritis earlier than does conservative management. We provide electrodiagnostic evidence that combined ONTT regimen–compared with conservative management–results in early remission of visual conduction abnormalities in first-episode optic neuritis. |
Databáze: | OpenAIRE |
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