Signification of Serum Alpha-Fetoprotein Levels in Cases of Compensated Cirrhosis and Hepatitis C Virus without Hepatocellular Carcinoma
| Autor: | Irina Sandra, Gabriela Oprea-Calin, Cristian Baicus, Ileana Constantinescu, Daniela Elena Chiriac, Andrei Ovidiu Olteanu, Carmen Monica Preda, Daniela Manuc, Cosmin Alexandru Ciora, Teodora Manuc, Razvan Cerban, Lucian Negreanu, Cristian Tieranu, Andreea Elena Chifulescu, Mircea Manuc, Mircea Diculescu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Liver Cirrhosis Male hepatitis C virus medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Hepatitis C virus Hepacivirus Serum alpha-fetoprotein medicine.disease_cause Gastroenterology compensated liver cirrhosis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine FibroMax Humans Prospective Studies Stage (cooking) Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Hepatitis C digestive system diseases 030220 oncology & carcinogenesis Liver biopsy Hepatocellular carcinoma 030211 gastroenterology & hepatology Female Original Article alpha-Fetoproteins Alpha-fetoprotein (AFP) Steatosis business |
| Zdroj: | Journal of Medicine and Life |
| ISSN: | 1844-3117 |
| Popis: | AFP (alpha-fetoprotein) levels are increased during the development of HCC (hepatocellular carcinoma); nonetheless, it can also be produced by non-tumoral hepatocytes in conditions of high cell turnover. Our study aims to provide additional data regarding the causes of elevated AFP in patients with liver cirrhosis due to hepatitis C virus (HCV) infection. We conducted an observational prospective cohort study that included 2068 patients with compensated cirrhosis and chronic hepatitis C genotype 1b infection. The two main inclusion criteria were the presence of advanced liver fibrosis - Metavir stage F4 - diagnosed by FibroMax testing, Fibroscan or liver biopsy, and the presence of detectable HCV RNA in the serum. Plasmatic AFP levels were determined through the electrochemiluminescence method, with a standard value ranging from 0 to 7 ng/ml. All data were obtained from the Romanian National Health Agency. The average AFP serum levels in patients with compensated cirrhosis without HCC were 9.4 ng/ml (range 0.5 � 406 ng/ml); 30.1% of patients had significantly increased levels of AFP (>15 ng/ml). High values of serum AFP in patients with compensated liver cirrhosis without HCC was correlated with more advanced age (p |
| Databáze: | OpenAIRE |
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