Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia

Autor:	Karen Blindauer, Lauren Seeberger, Brian Wulbrecht, Joan Young, Victoria Hunt, Judith Dobson, Lisa Byder, Clifford W. Shults, Deborah Fontaine, William C. Nichols, P. Michael Conneally, Carolyn Peterson, Julie H. Carter, Hubert H. Fernandez, Margaret C. Lannon, William C. Koller, Joanne Wojcieszek, Lawrence Elmer, Jayaraman Rao, Mark Stacy, Jo Belden, Bala V. Manyam, Julie So, Theresa Shirley, Stephen G. Reich, Stephanie Thomas, John M. Bertoni, Peggy Gray, Marguerite Wieler, Anette Nieves, Rachel Saunders Pullman, Mayank Pathak, Kenneth Marek, Debra Berry, Holly Delgado, Christopher F. O'Brien, Anthony E. Lang, Karen Marder, Ali H. Rajput, Eric Siemers, Cheryl Halter, Michel Panisset, Galit Kleimer-Fisman, Kelly E. Lyons, Robyn Schacherer, Richard Camicioli, Tatiana Foroud, Alex Rajput, Carson Reider, Kathy Davis, Robert A. Hauser, Theresa A. Zesiewicz, Deborah Judd, Susan Mendick, Maryan De Angelis, Sandra Roque, Alice Rudolph, Becky Dunlop, An Tran, Maureen Cook, Christine Hunter, Daniel D. Truong, Stewart A. Factor, Michael J. Aminoff, David Oakes, Sharon Evans, Paul J. Tuite, Jean Hall, David Grimes, W.R. Wayne Martin, Magali Fernandez, Joanna Hamman, Francis O. Walker, Pam Andrews, Karyn Boyar, Juliette Harris, Tilak Mendis, Nathan Pankratz, Mariann DiMinno, Robert L. Rodnitzky, Rajesh Pahwa, Peter A. LeWitt, Jeannine Petit, William J. Weiner, Un Jung Kang, Joseph Jankovic, Ronald F. Pfeiffer, Aileen Shinaman, Jean P. Hubble, Mark Forrest Gordon, Danna Jennings, Joseph H. Friedman, Carmen Serrano Ramos, Roger Kurlan, Kelli Williamson, Brenda Pfeiffer, Frederick J. Marshall
Rok vydání:	2005
Předmět:	Apolipoprotein E Adult Lewy Body Disease Male Risk medicine.medical_specialty Pathology Parkinson's disease Adolescent Genotype Apolipoprotein E4 Statistics as Topic Disease Neuropsychological Tests Apolipoproteins E Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Allele Risk factor Alleles Aged Aged 80 and over Neurologic Examination business.industry Genetic Carrier Screening Homozygote Parkinson Disease Middle Aged medicine.disease Survival Analysis Neurology lipids (amino acids peptides and proteins) Female Neurology (clinical) Alzheimer's disease Age of onset business Mental Status Schedule
Zdroj:	Movement disorders : official journal of the Movement Disorder Society. 21(1)
ISSN:	0885-3185
Popis:	The epsilon4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neurodegenerative disorders, such as Parkinson's disease (PD). APOE genotype, age of onset, disease duration, smoking history, and dementia status were collected for families with PD, yielding 324 Caucasian families with complete information. Logistic regression employing one individual per family and including age of onset and disease duration as covariates demonstrated a significantly increased risk of dementia for those individuals having inherited at least one epsilon4 allele (OR=3.37; P=0.002). Survival analyses also demonstrated a significantly earlier age of onset for those subjects with at least one epsilon4 allele (59.7 years) as compared with those homozygous for the more common epsilon3 allele (62.4 years; P=0.009). Thus, consistent with previous studies, we find evidence that the presence of an epsilon4 allele results in significantly earlier onset of PD and a greater likelihood of dementia. It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dad4eef80e5b861c95a811d7fa272c1 https://pubmed.ncbi.nlm.nih.gov/16116614 Zobrazit plný text záznamu Plný text