Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition
| Autor: | Kervin Smith, Laurie B. Joseph, Yingyue Zhang, Kathryn E. Uhrich, Mary Joy Nova, Alysha Moretti, Jonathan J. Faig |
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| Rok vydání: | 2017 |
| Předmět: |
Polymers and Plastics
Polymers Cell Survival Tyrosinase Melanoma Experimental Biocompatible Materials Bioengineering 02 engineering and technology Article Polymerization Biomaterials Mice Experimental chemistry.chemical_compound Drug Delivery Systems Engineering Tumor Cells Cultured 0202 electrical engineering electronic engineering information engineering Materials Chemistry Animals Organic chemistry Photodegradation Melanoma Melanins chemistry.chemical_classification Cultured Chemistry Solution polymerization Polymer Biological Sciences 021001 nanoscience & nanotechnology Tumor Cells Polyester Pyrones Chemical Sciences NIH 3T3 Cells Degradation (geology) 020201 artificial intelligence & image processing 0210 nano-technology Kojic acid Linker |
| Zdroj: | Biomacromolecules, vol 18, iss 2 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Kojic acid (KA) is a naturally occurring fungal metabolite that is utilized as a skin-lightener and antibrowning agent owing to its potent tyrosinase inhibition activity. While efficacious, KA's inclination to undergo pH-mediated, thermal-, and photodegradation reduces its efficacy, necessitating stabilizing vehicles. To minimize degradation, poly(carbonate-esters) and polyesters comprised of KA and natural diacids were prepared via solution polymerization methods. In vitro hydrolytic degradation analyses revealed KA release was drastically influenced by polymer backbone composition (e.g., poly(carbonate-ester) vs polyester), linker molecule (aliphatic vs heteroatom-containing), and release conditions (physiological vs skin). Tyrosinase inhibition assays demonstrated that aliphatic KA dienols, the major degradation product under skin conditions, were more potent then KA itself. All dienols were found to be less toxic than KA at all tested concentrations. Additionally, the most lipophilic dienols were statistically more effective than KA at inhibiting melanin biosynthesis in cells. These KA-based polymer systems deliver KA analogues with improved efficacy and cytocompatible profiles, making them ideal candidates for sustained topical treatments in both medical and personal care products. |
| Databáze: | OpenAIRE |
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