Registered Influenza Viral Vector Based Brucella abortus Vaccine for Cattle in Kazakhstan: Age-Wise Safety and Efficacy Studies
Autor: | Sholpan Ryskeldinova, Nadezhda Zinina, Zhailaubay Kydyrbayev, Bolat Yespembetov, Yerken Kozhamkulov, Dulat Inkarbekov, Nurika Assanzhanova, Aigerim Mailybayeva, Dina Bugybayeva, Makhpal Sarmykova, Berik Khairullin, Kairat Tabynov, Aitbay Bulashev, Batyrbek Aitzhanov, Khairulla Abeuov, Abylay Sansyzbay, Tlektes Yespolov, Gourapura J. Renukaradhya, Steven Olsen, Angel Oñate, Kaissar Tabynov |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Microbiology (medical) Booster vaccination Immunology Brucella Abortion Microbiology calves Viral vector 03 medical and health sciences 0302 clinical medicine vaccine medicine influenza viral vector 030212 general & internal medicine protective efficacy Pregnancy biology business.industry registration trials Clinical disease biology.organism_classification medicine.disease QR1-502 030104 developmental biology Infectious Diseases Granuloma Brucella abortus vaccine business bovine brucellosis |
Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
ISSN: | 2235-2988 |
Popis: | A novel influenza viral vector based Brucella abortus vaccine (Flu-BA) was introduced for use in cattle in Kazakhstan in 2019. In this study, the safety and efficacy of the vaccine was evaluated in male and female cattle at different ages, and during pregnancy as a part of its registration process. Our data demonstrated that the Flu-BA vaccine was safe after prime or booster vaccination in calves (5–7 months old male and female), heifers (15–17 months old) and cows (6–7 years old) and was not abortogenic in pregnant animals. A mild, localized granuloma was observed at the Flu-BA injection site. Vaccinated animals did not show signs of influenza infection or reduced milk production in dairy cows, and the influenza viral vector (IVV) was not recovered from nasal swabs or milk. Vaccinated animals in all age groups demonstrated increased IgG antibody responses against Brucella Omp16 and L7/L12 proteins with calves demonstrating the greatest increase in humoral responses. Following experimental challenge with B. abortus 544, vaccinates demonstrated greater protection and no signs of clinical disease, including abortion, were observed. The vaccine effectiveness against B. abortus 544 infection was 75, 60 and 60%, respectively, in calves, heifers and adult cows. Brucella were not isolated from calves of vaccinated cattle that were experimentally challenged during pregnancy. Our data suggests that the Flu-BA vaccine is safe and efficacious in cattle, including pregnant animals; and can therefore be administered to cattle of any age. |
Databáze: | OpenAIRE |
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