Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Autor: Popping, Stephanie, Verwijs, R, Cuypers, L, Claassen, Mark, van den Berk, GE, De Weggheleire, A, Arends, JEA, Boerekamps, Anne, Molenkamp, Richard, Koopmans, Marion, Verbon, Annelies, Boucher, Charles, Rijnders, Bart, Vijver, David, Lauw, F, Posthouwer, D, Hullegie, S, Bierman, W, Dofferhof, A, Kootstra, GJ, Leyten, E, Hollander, Jessica, van Kasteren, M, Soutekouw, R, Ammerlaan, H, Florence, E
Přispěvatelé: Virology, Medical Microbiology & Infectious Diseases, Gastroenterology & Hepatology, Internal Medicine, Erasmus MC other
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
hepatitis C virus
Hepacivirus
Viral Nonstructural Proteins
medicine.disease_cause
Men who have sex with men
Sexual and Gender Minorities
0302 clinical medicine
Genotype 1b
Medicine
the WHO 2030 elimination goals
Hepatitis C virus genotype determination
Phylogeny
Transmission (medicine)
virus diseases
INHIBITOR
Hepatitis C
AcademicSubjects/MED00290
Infectious Diseases
030211 gastroenterology & hepatology
Life Sciences & Biomedicine
Microbiology (medical)
Genotype
Hepatitis C virus
030106 microbiology
Immunology
Antiviral Agents
Microbiology
resistant associated substitutions
03 medical and health sciences
SDG 3 - Good Health and Well-being
Hepatitis C virus genotype
Drug Resistance
Viral
Humans
Homosexuality
Male
HIV co-infected MSM
NS5A
Online Only Articles
Q80K
Science & Technology
business.industry
phylogenetic analysis
Inhibitor resistance
Hepatitis C
Chronic
Virology
digestive system diseases
POLYMORPHISM
Brief Reports
business
Zdroj: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 71(8), E215-E217. Oxford University Press
ISSN: 1058-4838
Popis: The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS. ispartof: CLINICAL INFECTIOUS DISEASES vol:71 issue:8 pages:E215-E217 ispartof: location:United States status: published
Databáze: OpenAIRE
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