Treatment with intralesional granulocyte instillations and interferon-gamma for a patient with chronic granulomatous disease and multiple hepatic abscesses
| Autor: | Alan R. Baker, Richard Chang, Ellen S. DeCarlo, Susan F. Leitman, Judi T. Miller, Julie A. Lekstrom-Himes, John I. Gallin, Steven M. Holland |
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| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Blood transfusion Adolescent medicine.medical_treatment Liver Abscess Granulocyte Injections Intralesional medicine.disease_cause Granulomatous Disease Chronic Isoantibodies Interferon-gamma Chronic granulomatous disease Interferon γ Antibiotic therapy medicine Humans Hepatic Abscesses business.industry Staphylococcal Infections medicine.disease Combined Modality Therapy Surgery Anti-Bacterial Agents Leukocyte Transfusion Infectious Diseases medicine.anatomical_structure Staphylococcus aureus Drug Therapy Combination Female business Granulocytes |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 19(4) |
| ISSN: | 1058-4838 |
| Popis: | We present the case of a 16-year-old girl with p22-deficient chronic granulomatous disease in whom multiple hepatic abscesses secondary to Staphylococcus aureus infection developed. Infection persisted despite extensive surgery and aggressive antibiotic therapy. Conventional intravenous granulocyte transfusions were not tolerated because of the development of alloantibodies to HLA. Treatment with interferon-gamma and intralesional granulocyte infusions was associated with dramatic clinical and radiographic improvement. No morbidity was associated with this therapy. To our knowledge, this is the first report of treatment with intralesional granulocyte instillations. Intralesional granulocyte instillation in association with interferon-gamma administration may result in clinical improvement in the conditions of patients with chronic granulomatous disease and hepatic abscesses for whom conventional therapy has failed. |
| Databáze: | OpenAIRE |
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