Expert Panel Workshop Consensus Statement on the Role of the Environment in the Development of Autoimmune Disease
| Autor: | Noel R. Rose, Dori R. Germolec, Frederick W. Miller, Carlo Selmi, Kelly Joyce, Kenneth Michael Pollard, Michael C. Humble, Christine G. Parks |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology Disease onset exposure assessment Alternative medicine MEDLINE Review Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine medicine Genetic predisposition Humans autoimmune diseases Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy 030304 developmental biology Exposure assessment 030203 arthritis & rheumatology Autoimmune disease 0303 health sciences mechanisms Human studies business.industry Organic Chemistry General Medicine Environmental exposure Environmental Exposure medicine.disease 3. Good health Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 consensus Engineering ethics epidemiology environmental exposures business National Institute of Environmental Health Sciences (U.S.) |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 15, Iss 8, Pp 14269-14297 (2014) |
| ISSN: | 1422-0067 |
| Popis: | Autoimmune diseases include 80 or more complex disorders characterized by self-reactive, pathologic immune responses in which genetic susceptibility is largely insufficient to determine disease onset. In September 2010, the National Institute of Environmental Health Sciences (NIEHS) organized an expert panel workshop to evaluate the role of environmental factors in autoimmune diseases, and the state of the science regarding relevant mechanisms, animal models, and human studies. The objective of the workshop was to analyze the existing data to identify conclusions that could be drawn regarding environmental exposures and autoimmunity and to identify critical knowledge gaps and areas of uncertainty for future study. This consensus document summarizes key findings from published workshop monographs on areas in which “confident” and “likely” assessments were made, with recommendations for further research. Transcribed notes and slides were reviewed to synthesize an overview on exposure assessment and questions addressed by interdisciplinary panels. Critical advances in the field of autoimmune disease research have been made in the past decade. Collaborative translational and interdisciplinary research is needed to elucidate the role of environmental factors in autoimmune diseases. A focus on exposure assessment methodology is needed to improve the effectiveness of human studies, and more experimental studies are needed to focus on causal mechanisms underlying observed associations of environmental factors with autoimmune disease in humans. |
| Databáze: | OpenAIRE |
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