Intraarticular injection of Propionibacterium acnes causes an erosive arthritis in rats
| Autor: | J. M. Young, C. J. Evers, S. A. Ballaron, B. S. Trimble |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Cyclophosphamide Immunology Stifle joint Toxicology Injections Intra-Articular Propionibacterium acnes Synovitis Medicine Animals Pharmacology (medical) Dexamethasone Pharmacology Antigens Bacterial biology business.industry Cartilage Arthritis Hydroxychloroquine Rats Inbred Strains biology.organism_classification medicine.disease Sodium aurothiomalate Rats Disease Models Animal medicine.anatomical_structure business medicine.drug |
| Zdroj: | Agents and actions. 21(3-4) |
| ISSN: | 0065-4299 |
| Popis: | Formalin killed Propionibacterium acnes, was injected intraarticularly into the stifle joint of rats. The reaction was assessed by radiologic and histologic examination. A single injection induced a marginally erosive synovitis that receded by day 30. A second injection administered in the same joint resulted in tissue destruction that was evident radiographically. Treatment by dexamethasone and some disease modifying drugs, i.e. chloroquine, hydroxychloroquine, sodium aurothiomalate and cyclophosphamide, significantly inhibited cartilage and bone erosion while nonsteroidal antiinflammatory agents had no effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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