Evidence of oral translocation of anionic G6.5 dendrimers in mice
| Autor: | S. Sadekar, Hamidreza Ghandehari, Giridhar Thiagarajan, Khaled Greish, Abhijit Ray |
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| Rok vydání: | 2013 |
| Předmět: |
Dendrimers
Drug Carriers Chemistry Stomach Area under the curve Pharmaceutical Science Administration Oral Chromosomal translocation Pharmacology Article Bioavailability Intestines Mice In vivo Dendrimer Area Under Curve Drug Discovery Drug delivery Molecular Medicine Animals Amine gas treating Female Drug carrier |
| Zdroj: | Molecular pharmaceutics. 10(3) |
| ISSN: | 1543-8392 |
| Popis: | Development of carrier systems to improve oral bioavailability and target drugs to specific sites continues to be an unmet need. The goal of this study was to evaluate the potential of anionic generation (G) 6.5 poly(amido amine) (PAMAM) dendrimers in oral drug delivery by assessing their in vivo oral translocation. G6.5-COOH dendrimers were characterized for their physiochemical characteristics and acute oral toxicity was assessed in CD-1 mice. The dendrimers were labeled with (125)I and their stability evaluated. Oral bioavailability was assessed in the same mouse model. Investigation of the radioactivity profile in plasma revealed presence of both large and small molecular weight compounds. Detailed area under the curve analysis suggests an effective 9.4% bioavailability of radiolabeled marker associated with G6.5-COOH. Results reported here suggest the potential of dendrimers in permeating gastrointestinal barriers in vivo. |
| Databáze: | OpenAIRE |
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