Factors Influencing Sodium Reabsorption in the Distal Nephron
| Autor: | Gise F, Alfago E, Mendlowitz M, Levitt Mf, Pardalis Da, T Kahn, MH Goldstein |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Sodium chemistry.chemical_element Diuresis Chloride General Biochemistry Genetics and Molecular Biology Renal chloride reabsorption Excretion Dogs Renal Artery Urine flow rate Internal medicine medicine Animals Kidney Tubules Distal Renal sodium reabsorption urogenital system Reabsorption Osmolar Concentration Water-Electrolyte Balance Kidney Tubules Endocrinology chemistry Glomerular Filtration Rate medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 145:737-742 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-145-37886 |
| Popis: | SummaryIn 16 of 25 studies during hypotonic sodium sulfate infusion, the development of a chloruresis was temporally associated with a maximal level of CH2O In nine studies, no chloride diuresis developed, and CH2O remained lower than in the former group despite the attainment of similar levels of solute excretion and urine flow rate. With renal-artery constriction, a close relationship was also demonstrated between the level of CH2O and the supply of sodium chloride to the distal nephron. The level of CH2O attained did not relate to levels of solute excretion, urine, flow rate, or intratubular chloride concentration. However, a direct linear relationship was observed between the maximal level of CH2O and GFR over a range of GFR from 15 to 51 ml/min. These findings support the view that a maximal level of CH2O represents a limit in sodium chloride reabsorption in the distal nephron and suggest that the capacity of the distal nephron to reabsorb sodium chloride is influenced by those factors determining th... |
| Databáze: | OpenAIRE |
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