Food intake during tumor growth: Anorexia in genetically obese ob/ob mice and hyperphagia in lean mice☆
| Autor: | John W. Kreider, David L. Margules, Carl I. Thompson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Food intake Skin Neoplasms Ratón Mammary gland Appetite Mice Obese Experimental and Cognitive Psychology Anorexia Hyperphagia Biology Cell Line Metastasis Feeding and Eating Disorders Eating Mice Behavioral Neuroscience Internal medicine medicine Animals Humans Tumor growth Obesity Melanoma Body Weight Prognosis medicine.disease Mice Inbred C57BL Endocrinology medicine.anatomical_structure Female medicine.symptom Energy Intake B16 melanoma |
| Zdroj: | Physiology & Behavior. 32:935-939 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(84)90281-6 |
| Popis: | Recent findings indicate that obese ( ob/ob ) mice suffer a low incidence of lung metastasis and survive longer than lean (+/?) littermates following injection with B16 melanoma cells [34]. The present study examined the food intake of obese and lean mice during the growth of this tumor. Mice from both groups increased their food intake by small and approximately equal amounts during the first three quarters of the survival period following injection with 10 6 cells, and body weights remained fairly stable. During the final quarter, however, obese mice became anorexic whereas lean mice became intensely hyperphagic; body weights changed accordingly. Thus, food intake is differentially affected by tumor growth in this form of genetic obesity. |
| Databáze: | OpenAIRE |
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