Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity
| Autor: | Christopher Dye, S. Pyke, Clive R. Davies, E. A. Llanos-Cuentas |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Epidemiology Cross-sectional study Recurrence Peru Prevalence Prospective Studies Child Subclinical infection Aged 80 and over biology Incidence (epidemiology) Incidence Middle Aged Infectious Diseases Immunity Active Child Preschool Protozoan Population study Female Human Research Article Adult medicine.medical_specialty Adolescent Leishmaniasis Cutaneous Antigens Protozoan purl.org/pe-repo/ocde/ford#3.03.08 [https] Leishmania braziliensis Age Distribution Cutaneous leishmaniasis Internal medicine medicine Animals Humans Antigens Support Non-U.S. Gov't Aged Skin Tests Animal business.industry Infant Leishmaniasis medicine.disease biology.organism_classification Cross-Sectional Studies Immunology business |
| Zdroj: | Epidemiology and infection. 114(2) |
| ISSN: | 0950-2688 |
| Popis: | SummaryA prospective longitudinal survey of cutaneous leishmaniasis (Leishmania peruviana) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura). Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72% (3418) of the study population. Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases; 497 people received a second MST at the end of the study. Analysis of the epidemiological data indicated that (i) 17% (16/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73·9 % protective immunity (95 % C.I. 53·0–85·5 %) and relatively permanent MST responsiveness (recovery rate = 0·0098/year; 95% C.I. 0·000–0·020/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17·9% per mm; P < 0·0001), and a mean MST recovery rate of 0·114/year (4/421 man-months), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections. |
| Databáze: | OpenAIRE |
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