Placental site trophoblastic tumor (PSTT) with multiple metastases and extremely poor prognosis
| Autor: | Mitsuhiro Nokubi, Ryo Konno, Takako Ohmaru, Hiromitsu Yamakawa, Sachiho Netsu |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Vincristine medicine.medical_treatment Biopsy Trophoblastic Tumor Gastroenterology Metastasis Trophoblastic Tumor Placental Site Fatal Outcome Surgical oncology Pregnancy Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Mitotic Index Humans Neoplasm Invasiveness Treatment Failure Placental site trophoblastic tumor Cyclophosphamide Etoposide Chemotherapy medicine.diagnostic_test Gestational trophoblastic disease business.industry Cell Differentiation Hematology General Medicine medicine.disease Magnetic Resonance Imaging Methotrexate Oncology Drug Resistance Neoplasm Uterine Neoplasms Dactinomycin Surgery Female business Tomography X-Ray Computed medicine.drug |
| Zdroj: | International journal of clinical oncology. 14(5) |
| ISSN: | 1437-7772 |
| Popis: | Placental site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic disease. There is a wide clinical spectrum of presentation and behavior ranging from a benign condition to an aggressive disease with a fatal outcome. PSTT limited to the uterus is in a good prognosis group, but PSTT with metastasis is a lethal disease. We document a case of PSTT with multiple metastases and extremely poor prognosis. A 36-year-old woman had abnormal irregular vaginal bleeding 14 months after her third pregnancy and delivery. The mitotic count of the tumor cells was quite high (23/10 high-power fields). It would have been difficult to remove the tumor by surgery because of the tumor size and its invasion, so we suggested chemotherapy. We treated her with EMA/CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, vincristine) as a first-line regimen. During the sixth cycle of EMA/CO, the disease became drug-resistant and she died 8 months after the first symptom. This was a rare case among documented patients with PSTT with metastasis, with the patient having short-term survival ( |
| Databáze: | OpenAIRE |
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