Cloning and expression analysis of the chick ortholog of TBX22, the gene mutated in X-linked cleft palate and ankyloglossia
| Autor: | Markus Pfordt, Corina Schmidt, Andreas Kispert, Bénédicte Haenig, Florian Kraus |
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| Rok vydání: | 2002 |
| Předmět: |
Embryology
TBX22 DNA Complementary Genetic Linkage Mesenchyme Molecular Sequence Data Chick Embryo Biology Myotome medicine Animals Humans Gene family Amino Acid Sequence Cloning Molecular Gene In Situ Hybridization Genetics Chromosomes Human X Lingual Frenum Base Sequence Sequence Homology Amino Acid Gene Expression Regulation Developmental Cleft Palate Somite medicine.anatomical_structure T-box Somites Mutation Secondary palate T-Box Domain Proteins Chickens Developmental Biology |
| Zdroj: | Mechanisms of Development. 117:321-325 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(02)00196-x |
| Popis: | T-box genes constitute a conserved gene family with important roles in many developmental processes. Several family members have been implicated in human congenital diseases. Recently, mutations in TBX22 were found to cause X-linked cleft palate (CPX and ankyloglossia), a semidominant X-linked disorder affecting formation of the secondary palate. Here, we have cloned the chick ortholog of human TBX22 and have analyzed its expression during embryogenesis. Expression is very prominent in the somites and in the myotome, and in the mandible and maxilla of the developing jaw. Other sites of expression include the limbs, the cranial mesenchyme and the eye. Hence, Tbx22 expression domains encompass the regions important for the development of the disease phenotype. |
| Databáze: | OpenAIRE |
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