Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
| Autor: | April L. Gilbert, Zachary W. Smith, Giacomo Bruno, Pramod N. Nehete, Alessandro Grattoni, Marco Folci, Kathryn A. Shelton, Lorraine R Hill, Jagannadha K. Sastry, Corrine Ying Xuan Chua, Carly S. Filgueira, Keith A. Youker, Priya Jain, Andrea Ballerini, Areeba Ali |
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| Rok vydání: | 2018 |
| Předmět: |
Biomedical Engineering
030209 endocrinology & metabolism White adipose tissue Type 2 diabetes 030204 cardiovascular system & hematology Acetates Bioinformatics 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Phenols Weight loss Medicine Animals Nanotechnology Sobetirome Obesity Molecular Biology Cardiotoxicity biology business.industry medicine.disease biology.organism_classification Macaca mulatta Rhesus macaque Implant medicine.symptom business |
| Zdroj: | Biomedical microdevices. 20(2) |
| ISSN: | 1572-8781 |
| Popis: | With nearly 40% of U.S. adults obese, and childhood and adolescent rates rising, obesity and associated comorbidities are serious public health concerns with massive societal costs. Often, lifestyle interventions do not offer sufficient weight loss to improve health, requiring surgery and medications as adjunct management strategies. Here, we present a 4-month case study in which the sustained, low-dose, and constant administration of the thyroid receptor β selective agonist GC-1 (sobetirome) from a novel nanochannel membrane implant was assessed in an obese, pre-diabetic rhesus macaque. Dramatic loss of white adipose tissue in the abdomen from 36 to 18% was observed via magnetic resonance imaging in conjunction with normalized serum insulin and glycemia, with no signs of cardiotoxicity shown. The non-human primate study highlights sustained low-dose delivery of GC-1 from our minimally invasive subcutaneous implant as a valuable approach to induce weight loss and manage obesity and comorbidities, including type 2 diabetes. |
| Databáze: | OpenAIRE |
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