Sporadic white sponge nevus caused by a mutation in the keratin 4 gene
| Autor: | Isao Miyamoto, A. Kasamatsu, Harusachi Kanazawa, Nao Ishida, Akihiro Kita, Katsuhiro Uzawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty lcsh:Surgery Lesion 03 medical and health sciences Exon 0302 clinical medicine Antibiotics White sponge nevus medicine Missense mutation Keratin 4 (KRT4) biology business.industry Sporadic case lcsh:RD1-811 030206 dentistry biochemical phenomena metabolism and nutrition medicine.disease White (mutation) Otorhinolaryngology Keratin 4 030220 oncology & carcinogenesis Mutation (genetic algorithm) biology.protein Mutation testing Surgery Oral Surgery medicine.symptom business |
| Zdroj: | Oral and Maxillofacial Surgery Cases, Vol 6, Iss 4, Pp 100190-(2020) |
| ISSN: | 2214-5419 |
| DOI: | 10.1016/j.omsc.2020.100190 |
| Popis: | Herein, we present a sporadic case of white sponge nevus (WSN) on the cheek mucosa in a 27-year-old Japanese man. A definite diagnosis of WSN was obtained using the typical clinical appearance and microscopic features of the lesions. Histopathological and cytological studies should be conducted to differentiate this condition from other oral premalignant white lesions. A molecular mutation analysis revealed a missense mutation in exon 1A of the keratin 4 gene, which is correlated with the development of WSN. Hence, genetic analysis must be performed to obtain an accurate diagnosis in sporadic cases. The temporary regression of the lesion after treatment with oral amoxicillin hydrate (AMPC) 750 mg/day indicates that antibiotics are effective in symptomatic cases. |
| Databáze: | OpenAIRE |
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