Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs
| Autor: | Serpil Erdogan, Halef Okan Doğan, Serpil Erşan, Murat Alisik, Huseyin Aydin, Sevtap Bakir, Derya Koç, Ozcan Erel, Etem Erdal Erşan |
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| Přispěvatelé: | [Dogan, Halef Okan -- Aydin, Huseyin -- Ersan, Serpil -- Bakir, Sevtap -- Koc, Derya] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Ersan, Etem Erdal] Sivas Numune Hosp, Dept Psychiat, Sivas, Turkey -- [Erdogan, Serpil -- Alisik, Murat -- Erel, Ozcan] Ankara Ataturk Educ & Res Hosp, Dept Clin Biochem, Ankara, Turkey, Alisik, Murat -- 0000-0003-0434-3206 |
| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Atypical antipsychotic Oxidative phosphorylation Pharmacology medicine.disease_cause 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Thiols medicine Antipsychotics Pharmacology (medical) Disulfides Antipsychotic chemistry.chemical_classification business.industry Therapeutic effect medicine.disease 030227 psychiatry Psychiatry and Mental health chemistry Schizophrenia Thiol Population study Original Article business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| DOI: | 10.9758/cpn.2018.16.1.39 |
| Popis: | WOS: 000425540200005 PubMed ID: 29397665 Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs. Methods: Thirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population. Results: The TAS (p=0.001), total thiol, and native thiol levels (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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