PV network plasticity mediated by neuregulin1-ErbB4 signalling controls fear extinction
| Autor: | Jian-Ming Yang, Tian-Ming Gao, Sheng-Rong Zhang, Jing-Ting Li, Yun-Long Song, Zheng-Yi Luo, Shi-Zhong Zhang, Jian-Lin Wu, Meng-Ling Wang, Neng-Yuan Hu, Xiao-Wen Li, Lang Huang, Yi-Hua Chen, Lin-Lin Bi, Wu Dingyu, Wei Jie |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Receptor ErbB-4 Neuregulin-1 Prefrontal Cortex Amygdala Extinction Psychological Cellular and Molecular Neuroscience Mice Neuroplasticity Biological neural network medicine Premovement neuronal activity Animals Prefrontal cortex Molecular Biology Neuronal Plasticity biology Extinction (psychology) Fear Psychiatry and Mental health medicine.anatomical_structure Parvalbumins nervous system biology.protein Neuregulin Neuroscience Parvalbumin |
| Zdroj: | Molecular psychiatry. 27(2) |
| ISSN: | 1476-5578 |
| Popis: | Neuroplasticity in the medial prefrontal cortex (mPFC) is essential for fear extinction, the process of which forms the basis of the general therapeutic process used to treat human fear disorders. However, the underlying molecules and local circuit elements controlling neuronal activity and concomitant induction of plasticity remain unclear. Here we show that sustained plasticity of the parvalbumin (PV) neuronal network in the infralimbic (IL) mPFC is required for fear extinction in adult male mice and identify the involvement of neuregulin 1-ErbB4 signalling in PV network plasticity-mediated fear extinction. Moreover, regulation of fear extinction by basal medial amygdala (BMA)-projecting IL neurons is dependent on PV network configuration. Together, these results uncover the local molecular circuit mechanisms underlying mPFC-mediated top-down control of fear extinction, suggesting alterative therapeutic approaches to treat fear disorders. |
| Databáze: | OpenAIRE |
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