The effect of topiramate versus flunarizine on the non-headache symptoms of migraine
| Autor: | Wei Li, Guolei Li, Ruiting Liu, Chunfu Chen, Weidong Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Topiramate endocrine system medicine.medical_specialty business.industry General Neuroscience General Medicine medicine.disease Prolactin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Migraine Dopamine Internal medicine Medicine sense organs skin and connective tissue diseases business Flunarizine hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Journal of Neuroscience. 133:19-25 |
| ISSN: | 1543-5245 0020-7454 |
| Popis: | To investigate the impact of topiramate versus flunarizine on the non-headache symptoms (NHS) of migraine, and to observe the changes of dopamine (DA) and prolactin (PRL) before and after prophylactic treatment.Sixty-six episodic migraine patients were enrolled and randomized 1:1 to receive either flunarizine or topiramate treatment. Clinical characteristics and NHS associated with migraine were investigated before and after prophylactic treatment. The DA and PRL levels were also determined before and after prophylactic treatment.The NHS of migraine in the two groups were significantly better after treatment than before treatment in premonitory phase (PP), headache phase (HP), and resolution phase (RP). The NHS in the two groups had no significant difference in PP, HP, and RP before and after treatment. In the flunarizine group, the PRL content after treatment was significantly higher than that before treatment (The two classical prophylactic drugs of migraine were significantly effective in treating the NHS of migraine, but there was no significant difference between the two drugs. The DA-PRL axis may be involved in the underlying mechanism of the flunarizine treatment for the NHS of migraine. |
| Databáze: | OpenAIRE |
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