Efficacy of ciprofloxacin versus doxycycline as prophylaxis against experimental murine Brucella melitensis infection
| Autor: | Alastair P. MacMillan, P. Russell, Andrew J. H. Simpson, Stephen Spencer, Stephen M. Eley, Helen S. Atkins, Dominic C. Jenner, Simon D. Brew |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics Colony Count Microbial Brucella Brucellosis Microbiology Mice Ciprofloxacin Brucella melitensis medicine Animals Humans Pharmacology (medical) Antibacterial agent Doxycycline Mice Inbred BALB C biology General Medicine Antibiotic Prophylaxis biology.organism_classification medicine.disease Anti-Bacterial Agents Treatment Outcome Infectious Diseases Immunology Chemoprophylaxis Female Spleen medicine.drug |
| Zdroj: | International Journal of Antimicrobial Agents. 34:474-476 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2009.04.006 |
| Popis: | The prophylactic potential of ciprofloxacin was assessed in comparison with doxycycline, an established therapeutic antibiotic, to limit or control infection by Brucella melitensis in an experimental mouse model. Ciprofloxacin treatment reduced bacterial loads in the spleens of challenged mice when administered prior to or at the same time as the bacterial challenge. In comparison, doxycycline provided much greater reductions in bacterial counts, even when treatment was initiated after infection. Doxycycline was able to protect against B. melitensis when administered for 5 days from 24 h after infection and for at least 28 days after cessation of the antibiotic. Overall, these results confirm that ciprofloxacin is less effective than doxycycline but suggest that it may have some utility in providing protection against low-level infections. Combination studies are indicated. |
| Databáze: | OpenAIRE |
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