Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study
| Autor: | José Carlos Jaime-Pérez, David Gómez-Almaguer, Mario C. Salinas-Carmona, Humberto Treviño-Villarreal, Sandra Nora González-Díaz, Raúl Cavazos-González, Gabriela Galindo-Rodríguez, Alberto Carlos Heredia-Salazar, Ángeles Castro-Corona |
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| Rok vydání: | 2017 |
| Předmět: |
Allergy
Asparaginase medicine.medical_treatment Silent antibodies Acute lymphoblastic leukemia Immunoglobulin E Neutralizing antibodies Immunoglobulin G Flow cytometry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Hypersensitivity Childhood Acute Lymphoblastic Leukemia Chemotherapy medicine.diagnostic_test biology business.industry lcsh:RC633-647.5 lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease l-Asparaginase chemistry 030220 oncology & carcinogenesis Immunology biology.protein Original Article Antibody business 030215 immunology |
| Zdroj: | Revista Brasileira de Hematologia e Hemoterapia v.39 n.3 2017 Revista brasileira de hematologia e hemoterapia Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC Revista Brasileira de Hematologia e Hemoterapia, Vol 39, Iss 3, Pp 202-209 Revista Brasileira de Hematologia e Hemoterapia, Volume: 39, Issue: 3, Pages: 202-209, Published: SEP 2017 Revista Brasileira de Hematologia e Hemoterapia |
| ISSN: | 1516-8484 |
| DOI: | 10.1016/j.bjhh.2016.11.006 |
| Popis: | Background l -Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti- l -asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity reactions, in which immunoglobulin E can also participate. This study investigated the presence of immunoglobulin G and immunoglobulin E anti- l -asparaginase antibodies and their clinical associations. Methods Under 16-year-old patients at diagnosis of B-cell acute lymphoblastic leukemia confirmed by flow cytometry and treated with a uniform l -asparaginase and chemotherapy protocol were studied. Immunoglobulin G anti- l -asparaginase antibodies were measured using an enzyme-linked immunosorbent assay. Intradermal and prick skin testing was performed to establish the presence of specific immunoglobulin E anti- l -asparaginase antibodies in vivo . Statistical analysis was used to investigate associations of these antibodies with relevant clinical events and outcomes. Results Fifty-one children were studied with 42 (82.35%) having anti- l -asparaginase antibodies. In this group immunoglobulin G antibodies alone were documented in 10 (23.8%) compared to immunoglobulin E alone in 18 (42.8%) patients. Immunoglobulin G together with immunoglobulin E were simultaneously present in 14 patients. Children who produced exclusively immunoglobulin G or no antibodies had a lower event-free survival ( p -value = 0.024). Eighteen children (35.3%) relapsed with five of nine of this group who had negative skin tests suffering additional relapses (range: 2–4), compared to none of the nine children who relapsed who had positive skin tests ( p -value Conclusion Children with acute lymphoblastic leukemia and isolated immunoglobulin G anti- l -asparaginase antibodies had a higher relapse rate, whereas no additional relapses developed in children with immunoglobulin E anti- l -asparaginase antibodies after the first relapse. |
| Databáze: | OpenAIRE |
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