Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex
| Autor: | Ilana B. Witten, Julia Cox, Varun Bhave, Alexander R. Nectow, Nathan F. Parker, Hee Jae Jang, Malavika Murugan, Hong Hur, Ellia M. Miller, Michelle Park, Jonathan W. Pillow, Joshua P. Taliaferro, Yupu Liang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Infralimbic cortex Prefrontal Cortex Spatial Behavior Nucleus accumbens Optogenetics Biology Amygdala Nucleus Accumbens General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Limbic system Neural Pathways Limbic System medicine Animals Learning Social Behavior Prefrontal cortex Neurons Ventral Tegmental Area Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Neuroscience 030217 neurology & neurosurgery Social behavior |
| Zdroj: | Cell. 171:1663-1677.e16 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2017.11.002 |
| Popis: | Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which neurons are relevant or how they contribute. We found that PL contains anatomically and molecularly distinct subpopulations that target three downstream regions that have been implicated in social behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental area. Activation of NAc-projecting PL neurons (PL-NAc), but not the other subpopulations, decreased the preference for a social target. To determine what information PL-NAc neurons convey, we selectively recorded from them and found that individual neurons were active during social investigation, but only in specific spatial locations. Spatially specific manipulation of these neurons bidirectionally regulated the formation of a social-spatial association. Thus, the unexpected combination of social and spatial information within the PL-NAc may contribute to social behavior by supporting social-spatial learning. |
| Databáze: | OpenAIRE |
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