Bovine Lymphocyte Antigens (BoLA): A Serologic, Genetic and Histocompatibility Analysis
| Autor: | B. Amorena, W. H. Stone |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Genotype Immunology Locus (genetics) Major histocompatibility complex Biochemistry Absorption Serology Antigen Histocompatibility Antigens Genetics Animals Immunology and Allergy Lymphocytes Allele Pan-T antigens Alleles biology Immune Sera Graft Survival Skin Transplantation General Medicine Virology Pedigree Histocompatibility Meiosis biology.protein Cattle Female Lymphocyte Culture Test Mixed Antibody |
| Zdroj: | Tissue Antigens. 16:212-225 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1980.tb00297.x |
| Popis: | Eleven lymphocyte antigens have been defined in cattle using 81 lymphocytotoxic sera. These sera (typing reagents) were selected from over 1,000 normal sera, 35 alloimmune sera, and 111 samples of colostrum whey. Absorptions revealed that nine of the 11 antigens detected by these reagents are serologically independent. Segregation of the genes controlling these antigens was observed among 470 calves from matings of 56 heterozygous sires and 360 dams, indicating that each of the 11 antigens is controlled by one of 11 alleles at a single autosomal co-dominant locus BoLA–A (Bovine Lymphocyte Antigen, locus A). To determine the relation between BoLA antigens and histocompatibility, skin allografts were exchanged among four unrelated adult cows. Incompatibilities for the SD antigens, but not MLR or blood group antigens, were predictive of early rejection of allografts. Furthermore, graft recipients produced antibodies against the SD antigens of incompatible donors. These results indicate that the BoLA–A locus is part of the major histocompatibility complex (MHC) of cattle. |
| Databáze: | OpenAIRE |
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