Hydroalcoholic extract ofCarum carviL. in oral mucositis: a clinical trial in male golden hamsters
| Autor: | Azadeh Andisheh Tadbir, F Modarresi, Nader Tanideh, Aida Iraji, Omid Koohi-Hosseinabadi, Masood Sepehrimanesh, SM Afra, Maryam Mardani |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Carum law.invention 0403 veterinary science Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-Infective Agents Double-Blind Method Cheek pouch law Cricetinae Malondialdehyde Staphylococcus epidermidis medicine Mucositis Animals General Dentistry Essential oil Stomatitis Mesocricetus integumentary system biology Traditional medicine Plant Extracts business.industry Mouth Mucosa 030206 dentistry 04 agricultural and veterinary sciences medicine.disease biology.organism_classification Glutathione Surgery Oxidative Stress Otorhinolaryngology Carum carvi chemistry Histopathology Fluorouracil Streptococcus intermedius business |
| Zdroj: | Oral Diseases. 22:39-45 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/odi.12375 |
| Popis: | Objectives Several studies have attempted to prevent or improve oral mucositis (OM) but have not produced a qualified treatment yet. This study evaluates the effects of Carum carvi L. (caraway) hydroalcoholic extract (CHE) as one of the traditional medicinal plants in 5-fluorouracil (5-FU)-induced OM in golden hamsters. Materials and methods OM was induced in 54 male golden hamsters by 5-FU and cheek pouch scratching. Starting from day 12, 500 and 1000 mg kg−1 per day topical CHE were administered. Pouch histopathology score, malondialdehyde and reduced glutathione contents, and activity of myeloperoxidase plus microbial cultures of cheek pouch, antimicrobial properties of CHE, and essential oil constituents were evaluated. Results Lower histopathology score (0, 1, and 2) and malondialdehyde level, higher reduced glutathione level and activities of myeloperoxidase were detected in 1000 and 500 mg kg−1 per day topical CHE and control groups, respectively (P |
| Databáze: | OpenAIRE |
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