Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis
| Autor: | Shigehiro Ohdo, Shun Higuchi, Masao Minemoto, Fumihiro Suematsu, Miho Yukawa, Eiji Yukawa, Yoshinobu Goto |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Digoxin Adolescent Nifedipine Metabolic Clearance Rate medicine.drug_class Pharmaceutical Science Renal function Calcium channel blocker Spironolactone Pharmacology Models Biological Diltiazem Oral administration Humans Medicine Drug Interactions Pharmacology (medical) cardiovascular diseases Aged Aged 80 and over Heart Failure Models Statistical business.industry Pharmacoepidemiology Calcium channel Reproducibility of Results General Medicine Middle Aged Calcium Channel Blockers Verapamil Creatinine Regression Analysis Female business Algorithms circulatory and respiratory physiology medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 23:173-181 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.306 |
| Popis: | Nonlinear mixed effects modeling was used to estimate the effects of digoxin-calcium channel blockers (verapamil, diltiazem, nifedipine) in 336 serum levels gathered from 172 patients (104 male and 68 female) receiving oral digoxin as hospital in-patients. The final model describing digoxin clearance (CL) was CL (l/day)=(87.9+2.71C(cr))0.872(CCB)0.880(CHF)0.937(SPI)0.854(DFAC), where C(cr) is the estimated creatinine clearance (ml/min); CCB=1 for concomitant administration of calcium channel blockers and CCB=zero otherwise; CHF=1 for the patients with congestive heart failure and CHF=zero otherwise; SPI=1 for concomitant administration of spironolactone and SPI=zero otherwise; DFAC=1 for administration of a half-tablet of digoxin and DFAC=zero otherwise. Concomitant administration of calcium channel blockers resulted in a 13% decrease in digoxin relative clearance. |
| Databáze: | OpenAIRE |
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